Version 5.4
Homo sapiens Protein: IFT74
Summary
InnateDB Protein IDBP-55011.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFT74
Protein Name intraflagellar transport 74 homolog (Chlamydomonas)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000369402
InnateDB Gene IDBG-55009 (IFT74)
Protein Structure
UniProt Annotation
Function Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis. {ECO:0000269PubMed:23990561}.
Subcellular Localization Cell projection, cilium. Cytoplasmic vesicle. Note=Localizes along primary cilia at interphase and around the basal body/centriole at interphase and mitosis.
Disease Associations
Tissue Specificity Highly expressed in adult and fetal kidney and expressed at lower level in adult heart, placenta, lung, liver and pancreas, and in fetal heart, lung and liver. Little to no expression was detected in adult brain and skeletal muscle or in fetal brain, thymus and spleen. {ECO:0000269PubMed:11683410}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0048487 beta-tubulin binding
Biological Process
GO:0035735 intraciliary transport involved in cilium morphogenesis
GO:0042384 cilium assembly
Cellular Component
GO:0005813 centrosome
GO:0005929 cilium
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030992 intraciliary transport particle B
GO:0031514 motile cilium
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96LB3
PhosphoSite PhosphoSite-Q96LB3
TrEMBL E5RH29
UniProt Splice Variant
Entrez Gene 80173
UniGene Hs.145402
RefSeq NP_079379
HUGO HGNC:21424
OMIM 608040
CCDS CCDS43793
HPRD 09727
IMGT
EMBL AK023707 AK026274 AL355432 AL356133 AY040325 BC107742 BC113524 BX436367 CH471071
GenPept AAI07743 AAI13525 AAK77221 BAB14650 BAB15423 CAH72643 EAW58573

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca