Version 5.4
Homo sapiens Protein: PRPF18
Summary
InnateDB Protein IDBP-55252.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRPF18
Protein Name PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
Synonyms hPrp18; PRP18;
Species Homo sapiens
Ensembl Protein ENSP00000367835
InnateDB Gene IDBG-55250 (PRPF18)
Protein Structure
UniProt Annotation
Function Participates in the second step of pre-mRNA splicing. {ECO:0000269PubMed:9000057}.
Subcellular Localization Nucleus speckle {ECO:0000250}. Note=Colocalizes with spliceosomal snRNPs. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0019870 potassium channel inhibitor activity
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR003648 Splicing factor motif
IPR004098 Prp18
IPR014906 Pre-mRNA processing factor 4 (PRP4)-like
PFAM PF02840
PF08799
PRINTS
PIRSF
SMART SM00500
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99633
PhosphoSite PhosphoSite-Q99633
TrEMBL M0QXX3
UniProt Splice Variant
Entrez Gene 8559
UniGene Hs.729158
RefSeq NP_003666
HUGO HGNC:17351
OMIM 604993
CCDS CCDS7100
HPRD 05407
IMGT
EMBL AL157392 BC000794 BC002572 CH471072 U51990
GenPept AAB41490 AAH00794 CAI13123 EAW86281

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca