Version 5.4
Homo sapiens Protein: HAVCR1
Summary
InnateDB Protein IDBP-55261.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAVCR1
Protein Name hepatitis A virus cellular receptor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000344844
InnateDB Gene IDBG-55259 (HAVCR1)
Protein Structure
UniProt Annotation
Function May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair. {ECO:0000250, ECO:0000269PubMed:17471468, ECO:0000269PubMed:9658108}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses. {ECO:0000269PubMed:9658108}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0005515 protein binding
Biological Process
GO:0009615 response to virus
GO:0016032 viral process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96D42
PhosphoSite PhosphoSite-Q96D42
TrEMBL E5RIF6
UniProt Splice Variant
Entrez Gene 26762
UniGene Hs.129711
RefSeq NP_036338
HUGO HGNC:17866
OMIM 606518
CCDS CCDS43392
HPRD 09404
IMGT
EMBL AC026777 AF043724 BC013325 CR457114
GenPept AAC39862 AAH13325 CAG33395

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca