InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: XRCC1

Summary

InnateDB Protein

IDBP-55270.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XRCC1

Protein Name

X-ray repair complementing defective repair in Chinese hamster cells 1

Synonyms

RCC;

Species

Homo sapiens

Ensembl Protein

ENSP00000262887

InnateDB Gene

IDBG-55268 (XRCC1)

Protein Structure

UniProt Annotation

Function

Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17353262}. Note=Accumulates at sites of DNA damage.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	64 [view]
Protein-Protein	64 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0005515	protein binding

Biological Process

GO:0000012	single strand break repair
GO:0001666	response to hypoxia
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006974	cellular response to DNA damage stimulus
GO:0010033	response to organic substance
GO:0021766	hippocampus development
GO:0042493	response to drug