InnateDB Protein
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IDBP-55290.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SNRPG
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Protein Name
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small nuclear ribonucleoprotein polypeptide G
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Synonyms
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Sm-G; SMG;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000272348
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InnateDB Gene
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IDBG-55288 (SNRPG)
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Protein Structure
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Function |
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3'- end processing. {ECO:0000269PubMed:18984161, ECO:0000269PubMed:23333303}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000269PubMed:18984161}. Nucleus {ECO:0000269PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
50
[view]
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Protein-Protein |
49
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001163
Ribonucleoprotein LSM domain
IPR006649
Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920
Like-Sm (LSM) domain
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PFAM |
PF01423
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PRINTS |
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PIRSF |
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SMART |
SM00651
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TIGRFAMs |
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Modification |
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SwissProt |
P62308
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PhosphoSite |
PhosphoSite-P62308
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TrEMBL |
Q49AN9
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UniProt Splice Variant |
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Entrez Gene |
6637
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UniGene |
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RefSeq |
NP_003087
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HUGO |
HGNC:11163
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OMIM |
603542
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CCDS |
CCDS1903
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HPRD |
04646
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IMGT |
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EMBL |
AC079338
BC000070
BC022432
BC035103
BC066302
BC070166
BC071880
BC106055
CH471053
CR456918
X85373
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GenPept |
AAH00070
AAH22432
AAH35103
AAH66302
AAH70166
AAH71880
AAI06056
AAX81996
CAA59689
CAG33199
EAW99817
EAW99818
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