InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SART3

Summary

InnateDB Protein

IDBP-55335.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SART3

Protein Name

squamous cell carcinoma antigen recognized by T cells 3

Synonyms

DSAP1; P100; p110; p110(nrb); RP11-13G14; TIP110;

Species

Homo sapiens

Ensembl Protein

ENSP00000228284

InnateDB Gene

IDBG-55333 (SART3)

Protein Structure

UniProt Annotation

Function

Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. {ECO:0000269PubMed:11959860}.

Subcellular Localization

Cytoplasm. Nucleus speckle. Note=Localized in speckles. Expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver.

Disease Associations

Disseminated superficial actinic porokeratosis 1 (DSAP1) [MIM:175900]: Autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin. {ECO:0000269PubMed:15840095}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:11959860}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.

Experimentally validated
Total	93 [view]
Protein-Protein	91 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006396	RNA processing
GO:0010468	regulation of gene expression
GO:0048872	homeostasis of number of cells
GO:0071425	hematopoietic stem cell proliferation