InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLAUR

Summary

InnateDB Protein

IDBP-55444.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLAUR

Protein Name

plasminogen activator, urokinase receptor

Synonyms

CD87; U-PAR; UPAR; URKR;

Species

Homo sapiens

Ensembl Protein

ENSP00000342049

InnateDB Gene

IDBG-55442 (PLAUR)

Protein Structure

UniProt Annotation

Function

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

Subcellular Localization

Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.

Experimentally validated
Total	41 [view]
Protein-Protein	37 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0030377	U-plasminogen activator receptor activity

Biological Process

GO:0006501	C-terminal protein lipidation
GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0016255	attachment of GPI anchor to protein
GO:0030162	regulation of proteolysis
GO:0038195	urokinase plasminogen activator signaling pathway
GO:0042730	fibrinolysis
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0019898	extrinsic component of membrane
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome