Version 5.4
Homo sapiens Protein: GP9
Summary
InnateDB Protein IDBP-55496.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GP9
Protein Name glycoprotein IX (platelet)
Synonyms CD42a; GPIX;
Species Homo sapiens
Ensembl Protein ENSP00000303942
InnateDB Gene IDBG-55494 (GP9)
Protein Structure
UniProt Annotation
Function The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations Bernard-Soulier syndrome (BSS) [MIM:231200]: A coagulation disorder characterized by a prolonged bleeding time, unusually large platelets, thrombocytopenia, and impaired prothrombin consumption. {ECO:0000269PubMed:10583255, ECO:0000269PubMed:11167791, ECO:0000269PubMed:11758225, ECO:0000269PubMed:12100158, ECO:0000269PubMed:8481514, ECO:0000269PubMed:9163595, ECO:0000269PubMed:9886312}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007155 cell adhesion
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0030168 platelet activation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
PFAM PF01462
PF01463
PRINTS
PIRSF
SMART SM00013
SM00082
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P14770
PhosphoSite PhosphoSite-
TrEMBL D1MER8
UniProt Splice Variant
Entrez Gene 2815
UniGene Hs.1144
RefSeq NP_000165
HUGO HGNC:4444
OMIM 173515
CCDS CCDS3055
HPRD 01432
IMGT
EMBL BC030229 D88290 GU138098 M25827 M80478 X52997
GenPept AAA36809 AAB40042 AAH30229 ACZ44928 BAA13580 CAA37186

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca