InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CORO1C

Summary

InnateDB Protein

IDBP-55499.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CORO1C

Protein Name

coronin, actin binding protein, 1C

Synonyms

HCRNN4;

Species

Homo sapiens

Ensembl Protein

ENSP00000261401

InnateDB Gene

IDBG-55497 (CORO1C)

Protein Structure

UniProt Annotation

Function

May be involved in cytokinesis, motility, and signal transduction. {ECO:0000250}.Isoform 3: Involved in myogenic differentiation.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12377779}. Cell projection, lamellipodium {ECO:0000269PubMed:12377779}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:12377779}. Note=All isoforms localize in a diffuse and punctate pattern in the cytosol and are highly enriched in F-actin-rich areas. Isoform 3 colocalizes with the thin filaments of the sarcomere and with the postsynaptic area and the junctional sarcoplasm of motor end plates.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	48 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051015	actin filament binding

Biological Process

GO:0006909	phagocytosis
GO:0007165	signal transduction
GO:0030036	actin cytoskeleton organization

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR015048 Domain of unknown function DUF1899
IPR015049 Domain of unknown function DUF1900
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF08953
PF08954

PRINTS

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ULV4