InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DAO

Summary

InnateDB Protein

IDBP-55642.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAO

Protein Name

D-amino-acid oxidase

Synonyms

DAAO; DAMOX; OXDA;

Species

Homo sapiens

Ensembl Protein

ENSP00000228476

InnateDB Gene

IDBG-55640 (DAO)

Protein Structure

UniProt Annotation

Function

Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. {ECO:0000269PubMed:17303072}.

Subcellular Localization

Peroxisome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003884	D-amino-acid oxidase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0046983	protein dimerization activity
GO:0048037	cofactor binding
GO:0071949	FAD binding

Biological Process

GO:0006551	leucine metabolic process
GO:0006562	proline catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0036088	D-serine catabolic process
GO:0042416	dopamine biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046487	glyoxylate metabolic process
GO:0055114	oxidation-reduction process
GO:0055130	D-alanine catabolic process
GO:0070178	D-serine metabolic process