InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACACB

Summary

InnateDB Protein

IDBP-55823.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACACB

Protein Name

acetyl-CoA carboxylase beta

Synonyms

ACC2; ACCB; HACC275;

Species

Homo sapiens

Ensembl Protein

ENSP00000367079

InnateDB Gene

IDBG-55817 (ACACB)

Protein Structure

UniProt Annotation

Function

ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Subcellular Localization

Endomembrane system. Note=May associate with membranes.

Disease Associations

Tissue Specificity

Predominantly expressed in the heart, skeletal muscles and liver. {ECO:0000269PubMed:9099716}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003989	acetyl-CoA carboxylase activity
GO:0004075	biotin carboxylase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006084	acetyl-CoA metabolic process
GO:0006112	energy reserve metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006768	biotin metabolic process
GO:0006853	carnitine shuttle
GO:0008152	metabolic process
GO:0031325	positive regulation of cellular metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0051289	protein homotetramerization
GO:2001295	malonyl-CoA biosynthetic process

Cellular Component

GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0012505	endomembrane system

Protein Structure and Domains

PDB ID

InterPro

IPR000022 Carboxyl transferase
IPR000089 Biotin/lipoyl attachment
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005482 Biotin carboxylase, C-terminal
IPR011053 Single hybrid motif
IPR011054 Rudiment single hybrid motif
IPR011761 ATP-grasp fold
IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
IPR011764 Biotin carboxylation domain
IPR013537 Acetyl-CoA carboxylase, central domain
IPR016185 Pre-ATP-grasp domain
IPR029045 ClpP/crotonase-like domain

PFAM

PF01039
PF00364
PF02786
PF00289
PF02785
PF08326

PRINTS

PIRSF

SMART

SM00878

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00763