InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADRA1B

Summary

InnateDB Protein

IDBP-55925.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRA1B

Protein Name

adrenergic, alpha-1B-, receptor

Synonyms

ADRA1; ALPHA1BAR;

Species

Homo sapiens

Ensembl Protein

ENSP00000306662

InnateDB Gene

IDBG-55923 (ADRA1B)

Protein Structure

UniProt Annotation

Function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269PubMed:18802028, ECO:0000269PubMed:22120526}.

Subcellular Localization

Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004937	alpha1-adrenergic receptor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001974	blood vessel remodeling
GO:0001975	response to amphetamine
GO:0001987	vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007512	adult heart development
GO:0007626	locomotory behavior
GO:0008283	cell proliferation
GO:0008542	visual learning
GO:0016049	cell growth
GO:0019229	regulation of vasoconstriction
GO:0035265	organ growth
GO:0035556	intracellular signal transduction
GO:0042593	glucose homeostasis
GO:0043278	response to morphine
GO:0043410	positive regulation of MAPK cascade
GO:0045818	negative regulation of glycogen catabolic process
GO:0045819	positive regulation of glycogen catabolic process
GO:0048148	behavioral response to cocaine
GO:0055117	regulation of cardiac muscle contraction
GO:0071875	adrenergic receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001115 Alpha 1B adrenoceptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00556
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35368