InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADRA1B

Summary

InnateDB Gene

IDBG-55923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRA1B

Gene Name

adrenoceptor alpha 1B

Synonyms

ADRA1; ALPHA1BAR

Species

Homo sapiens

Ensembl Gene

ENSG00000170214

Encoded Proteins

IDBP-55925

adrenergic, alpha-1B-, receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:159916783-159972544

Strand

Forward strand

Band

q33.3

Transcripts

ENST00000306675

ENSP00000306662

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004937	alpha1-adrenergic receptor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001974	blood vessel remodeling
GO:0001975	response to amphetamine
GO:0001987	vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007512	adult heart development
GO:0007626	locomotory behavior
GO:0008283	cell proliferation
GO:0008542	visual learning
GO:0016049	cell growth
GO:0019229	regulation of vasoconstriction
GO:0035265	organ growth
GO:0035556	intracellular signal transduction
GO:0042593	glucose homeostasis
GO:0043278	response to morphine
GO:0043410	positive regulation of MAPK cascade
GO:0045818	negative regulation of glycogen catabolic process
GO:0045819	positive regulation of glycogen catabolic process
GO:0048148	behavioral response to cocaine
GO:0055117	regulation of cardiac muscle contraction
GO:0071875	adrenergic receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane