InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPEPPS

Summary

InnateDB Protein

IDBP-56028.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPEPPS

Protein Name

aminopeptidase puromycin sensitive

Synonyms

AAP-S; MP100; PSA;

Species

Homo sapiens

Ensembl Protein

ENSP00000320324

InnateDB Gene

IDBG-56026 (NPEPPS)

Protein Structure

UniProt Annotation

Function

Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. {ECO:0000269PubMed:10978616, ECO:0000269PubMed:11062501, ECO:0000269PubMed:17154549, ECO:0000269PubMed:17318184, ECO:0000269PubMed:19917696}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:10978616}. Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level). {ECO:0000269PubMed:10978616}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006508	proteolysis
GO:0071456	cellular response to hypoxia