Version 5.4
Homo sapiens Gene: NPEPPS
Summary
InnateDB Gene IDBG-56026.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPEPPS
Gene Name aminopeptidase puromycin sensitive
Synonyms AAP-S; MP100; PSA
Species Homo sapiens
Ensembl Gene ENSG00000141279
Encoded Proteins
IDBP-56028
aminopeptidase puromycin sensitive
IDBP-585311
aminopeptidase puromycin sensitive
IDBP-599050
aminopeptidase puromycin sensitive
IDBP-591566
aminopeptidase puromycin sensitive
IDBP-584038
aminopeptidase puromycin sensitive
IDBP-600067
aminopeptidase puromycin sensitive
IDBP-584511
aminopeptidase puromycin sensitive
IDBP-590323
aminopeptidase puromycin sensitive
IDBP-597271
aminopeptidase puromycin sensitive
IDBP-600856
aminopeptidase puromycin sensitive
IDBP-593821
aminopeptidase puromycin sensitive
IDBP-602182
aminopeptidase puromycin sensitive
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:47522942-47623276
Strand Forward strand
Band q21.32
Transcripts
ENST00000322157 ENSP00000320324
ENST00000525007 ENSP00000437019
ENST00000525037
ENST00000528751
ENST00000530173 ENSP00000433287
ENST00000526247 ENSP00000433735
ENST00000532729 ENSP00000434554
ENST00000533573
ENST00000527298 ENSP00000434585
ENST00000534691 ENSP00000433649
ENST00000527824
ENST00000534727
ENST00000534814
ENST00000525401
ENST00000527964 ENSP00000435639
ENST00000530514 ENSP00000436733
ENST00000527360 ENSP00000435966
ENST00000533538
ENST00000525021
ENST00000529602
ENST00000534807
ENST00000525048 ENSP00000432127
ENST00000531486
ENST00000528565 ENSP00000433549
ENST00000602788
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006508 proteolysis
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001441
View Gene Order
ENSBTAG00000011435
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.692439 Hs.740414
RefSeq NM_006310 XM_006722187
HUGO
OMIM
CCDS CCDS45721
HPRD 07366
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca