Homo sapiens Protein: SUV39H2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-56191.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | SUV39H2 | ||||||||||||||||||||||
Protein Name | suppressor of variegation 3-9 homolog 2 (Drosophila) | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000367576 | ||||||||||||||||||||||
InnateDB Gene | IDBG-56187 (SUV39H2) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. {ECO:0000269PubMed:14765126}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=Associates with centromeric constitutive heterochromatin. {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000953
Chromo domain/shadow IPR001214 SET domain IPR003616 Post-SET domain IPR011381 Histone H3-K9 methyltransferase IPR016197 Chromo domain-like IPR023780 Chromo domain |
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PFAM |
PF00856
PF00385 |
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PRINTS | |||||||||||||||||||||||
PIRSF |
PIRSF009343
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SMART |
SM00298
SM00317 SM00508 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q9H5I1 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9H5I1 | ||||||||||||||||||||||
TrEMBL | Q5JSS2 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 79723 | ||||||||||||||||||||||
UniGene | Hs.554883 | ||||||||||||||||||||||
RefSeq | NP_001180355 | ||||||||||||||||||||||
HUGO | HGNC:17287 | ||||||||||||||||||||||
OMIM | 606503 | ||||||||||||||||||||||
CCDS | CCDS53493 | ||||||||||||||||||||||
HPRD | 07580 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC069544 AK027067 AL360083 AL834488 BC007754 BC029360 CH471072 CR457372 | ||||||||||||||||||||||
GenPept | AAH07754 AAH29360 BAB15645 CAD39146 CAG33653 CAI40028 CAI40029 CAI40032 EAW86253 EAW86254 EAW86255 EAW86256 | ||||||||||||||||||||||