InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GABRB2

Summary

InnateDB Protein

IDBP-56271.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABRB2

Protein Name

gamma-aminobutyric acid (GABA) A receptor, beta 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000274547

InnateDB Gene

IDBG-56269 (GABRB2)

Protein Structure

UniProt Annotation

Function

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel. {ECO:0000269PubMed:19763268, ECO:0000269PubMed:8264558}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression. {ECO:0000269PubMed:16983389, ECO:0000269PubMed:19763268}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005237	inhibitory extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007268	synaptic transmission
GO:0007605	sensory perception of sound
GO:0034220	ion transmembrane transport
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0048666	neuron development
GO:0051932	synaptic transmission, GABAergic
GO:0055085	transmembrane transport
GO:0060119	inner ear receptor cell development
GO:0060384	innervation
GO:0071420	cellular response to histamine
GO:0090102	cochlea development
GO:1901215	negative regulation of neuron death
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0034707	chloride channel complex
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome
GO:1902711	GABA-A receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
IPR002289 Gamma-aminobutyric-acid A receptor, beta subunit
IPR005437 Gamma-aminobutyric-acid A receptor, gamma subunit
IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding

PFAM

PF02932
PF02931

PRINTS

PR01079
PR01160
PR01620
PR00253
PR00252

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P47870