InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GABRB2

Summary

InnateDB Gene

IDBG-56269.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABRB2

Gene Name

gamma-aminobutyric acid (GABA) A receptor, beta 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000145864

Encoded Proteins

IDBP-56271

gamma-aminobutyric acid (GABA) A receptor, beta 2

IDBP-56273

gamma-aminobutyric acid (GABA) A receptor, beta 2

IDBP-242571

gamma-aminobutyric acid (GABA) A receptor, beta 2

IDBP-484347

gamma-aminobutyric acid (GABA) A receptor, beta 2

IDBP-478492

gamma-aminobutyric acid (GABA) A receptor, beta 2

IDBP-478971

gamma-aminobutyric acid (GABA) A receptor, beta 2

IDBP-807622

gamma-aminobutyric acid (GABA) A receptor, beta 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:161288429-161549044

Strand

Reverse strand

Band

q34

Transcripts

ENST00000274547	ENSP00000274547
ENST00000353437	ENSP00000274546
ENST00000393959	ENSP00000377531
ENST00000520240	ENSP00000429320
ENST00000517901	ENSP00000430532
ENST00000517547	ENSP00000429750
ENST00000522758
ENST00000523730
ENST00000612710	ENSP00000480066

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005237	inhibitory extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0007165	signal transduction
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007268	synaptic transmission
GO:0007605	sensory perception of sound
GO:0034220	ion transmembrane transport
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0048666	neuron development
GO:0051932	synaptic transmission, GABAergic
GO:0055085	transmembrane transport
GO:0060119	inner ear receptor cell development
GO:0060384	innervation
GO:0071420	cellular response to histamine
GO:0090102	cochlea development
GO:1901215	negative regulation of neuron death
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0034707	chloride channel complex
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome
GO:1902711	GABA-A receptor complex