InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYVN1

Summary

InnateDB Protein

IDBP-56613.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYVN1

Protein Name

synovial apoptosis inhibitor 1, synoviolin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000366395

InnateDB Gene

IDBG-56611 (SYVN1)

Protein Structure

UniProt Annotation

Function

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. {ECO:0000269PubMed:12459480, ECO:0000269PubMed:12646171, ECO:0000269PubMed:12975321, ECO:0000269PubMed:14593114, ECO:0000269PubMed:16289116, ECO:0000269PubMed:16847254, ECO:0000269PubMed:17059562, ECO:0000269PubMed:17141218, ECO:0000269PubMed:17170702, ECO:0000269PubMed:22607976}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12459480, ECO:0000269PubMed:12646171, ECO:0000269PubMed:14593114, ECO:0000269PubMed:16186510}; Multi- pass membrane protein {ECO:0000269PubMed:12459480, ECO:0000269PubMed:12646171, ECO:0000269PubMed:14593114, ECO:0000269PubMed:16186510}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level). {ECO:0000269PubMed:12459480, ECO:0000269PubMed:12646171, ECO:0000269PubMed:12975321}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	73 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016881	acid-amino acid ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0016567	protein ubiquitination
GO:0018279	protein N-linked glycosylation via asparagine
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:1902236	negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress