Version 5.4
Homo sapiens Gene: SYVN1
Summary
InnateDB Gene IDBG-56611.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYVN1
Gene Name synovial apoptosis inhibitor 1, synoviolin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162298
Encoded Proteins
IDBP-56613
synovial apoptosis inhibitor 1, synoviolin
IDBP-56615
synovial apoptosis inhibitor 1, synoviolin
IDBP-56617
synovial apoptosis inhibitor 1, synoviolin
IDBP-602358
synovial apoptosis inhibitor 1, synoviolin
IDBP-596642
synovial apoptosis inhibitor 1, synoviolin
IDBP-584771
synovial apoptosis inhibitor 1, synoviolin
IDBP-603504
synovial apoptosis inhibitor 1, synoviolin
IDBP-593029
synovial apoptosis inhibitor 1, synoviolin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65121780-65134533
Strand Reverse strand
Band q13.1
Transcripts
ENST00000377190 ENSP00000366395
ENST00000294256 ENSP00000294256
ENST00000307289 ENSP00000302035
ENST00000449943
ENST00000530451
ENST00000526060 ENSP00000436984
ENST00000527765
ENST00000526121
ENST00000531018 ENSP00000431215
ENST00000532771 ENSP00000432166
ENST00000529207
ENST00000527142 ENSP00000432888
ENST00000528487 ENSP00000431720
ENST00000525874
ENST00000533685
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 74 [view]
Protein-Protein 73 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016881 acid-amino acid ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0016567 protein ubiquitination
GO:0018279 protein N-linked glycosylation via asparagine
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
GO:1902236 negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024807
View Gene Order
ENSBTAG00000005076
Not yet available
Pathways
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_228190
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_228209
Hh ligand biogenesis disease pathway
REACT_17015
Metabolism of proteins pathway
REACT_228111
Hedgehog ligand biogenesis pathway
REACT_116125
Disease pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q86TM6
TrEMBL E9PK19 E9PMA1 E9PN88
UniProt Splice Variant
Entrez Gene 84447
UniGene Hs.75859
RefSeq NM_032431 NM_172230
HUGO HGNC:20738
OMIM 608046
CCDS CCDS31605 CCDS8097
HPRD
IMGT
EMBL AB024690 AB058713 AB085847 AF317634 AL834262 AP003068 BC030530
GenPept AAH30530 AAL26903 BAB47439 BAC24801 BAC57449 CAD38937
RNA Seq Atlas 102465449 84447

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca