InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUSP11

Summary

InnateDB Protein

IDBP-56625.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP11

Protein Name

dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)

Synonyms

PIR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000272444

InnateDB Gene

IDBG-56623 (DUSP11)

Protein Structure

UniProt Annotation

Function

Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism. {ECO:0000269PubMed:10347225, ECO:0000269PubMed:24447265, ECO:0000269PubMed:9685386}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9685386}. Nucleus speckle {ECO:0000269PubMed:9685386}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	8 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004651	polynucleotide 5'-phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0044822	poly(A) RNA binding
GO:0098519	nucleotide phosphatase activity, acting on free nucleotides

Biological Process

GO:0006396	RNA processing
GO:0006470	protein dephosphorylation
GO:0016070	RNA metabolic process
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0098507	polynucleotide 5' dephosphorylation

Cellular Component

GO:0005634	nucleus
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

InterPro

IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00782

PRINTS

PIRSF

SMART

SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O75319