InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SKAP1

Summary

InnateDB Protein

IDBP-56655.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SKAP1

Protein Name

src kinase associated phosphoprotein 1

Synonyms

HEL-S-81p; SCAP1; SKAP55;

Species

Homo sapiens

Ensembl Protein

ENSP00000338171

InnateDB Gene

IDBG-56653 (SKAP1)

Protein Structure

UniProt Annotation

Function

Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. {ECO:0000269PubMed:10856234, ECO:0000269PubMed:11909961, ECO:0000269PubMed:12652296, ECO:0000269PubMed:15939789, ECO:0000269PubMed:16980616}.

Subcellular Localization

Cytoplasm. Nucleus. Cell membrane. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.

Disease Associations

Tissue Specificity

Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level). {ECO:0000269PubMed:9195899}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0032403	protein complex binding
GO:0042169	SH2 domain binding

Biological Process

GO:0009967	positive regulation of signal transduction
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050852	T cell receptor signaling pathway