InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACPP

Summary

InnateDB Protein

IDBP-56772.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACPP

Protein Name

acid phosphatase, prostate

Synonyms

5\'-NT; ACP-3; ACP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000337471

InnateDB Gene

IDBG-56768 (ACPP)

Protein Structure

UniProt Annotation

Function

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.Isoform 2: the cellular form also has ecto-5'- nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.

Subcellular Localization

Isoform 1: Secreted.Isoform 2: Cell membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane.

Disease Associations

Tissue Specificity

Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer. {ECO:0000269PubMed:17638863, ECO:0000269PubMed:21487525}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003993	acid phosphatase activity
GO:0005515	protein binding
GO:0008253	5'-nucleotidase activity
GO:0016791	phosphatase activity
GO:0042131	thiamine phosphate phosphatase activity
GO:0042802	identical protein binding
GO:0052642	lysophosphatidic acid phosphatase activity

Biological Process

GO:0006772	thiamine metabolic process
GO:0016311	dephosphorylation
GO:0046085	adenosine metabolic process
GO:0051930	regulation of sensory perception of pain
GO:0060168	positive regulation of adenosine receptor signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0012506	vesicle membrane
GO:0070062	extracellular vesicular exosome