InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DGUOK

Summary

InnateDB Protein

IDBP-56775.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGUOK

Protein Name

deoxyguanosine kinase

Synonyms

dGK; MTDPS3;

Species

Homo sapiens

Ensembl Protein

ENSP00000264093

InnateDB Gene

IDBG-56773 (DGUOK)

Protein Structure

UniProt Annotation

Function

Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents. {ECO:0000269PubMed:8706825}.

Subcellular Localization

Mitochondrion.

Disease Associations

Mitochondrial DNA depletion syndrome 3 (MTDPS3) [MIM:251880]: A disorder due to mitochondrial dysfunction characterized by onset in infancy of progressive liver failure, hypoglycemia, increased lactate in body fluids, and neurologic abnormalities including hypotonia, encephalopathy, peripheral neuropathy. Affected tissues show both decreased activity of the mtDNA-encoded respiratory chain complexes and mtDNA depletion. {ECO:0000269PubMed:12205643, ECO:0000269PubMed:15639197}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues. {ECO:0000269PubMed:8706825}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004138	deoxyguanosine kinase activity
GO:0005524	ATP binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019206	nucleoside kinase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006144	purine nucleobase metabolic process
GO:0006468	protein phosphorylation
GO:0008617	guanosine metabolic process
GO:0009157	deoxyribonucleoside monophosphate biosynthetic process
GO:0009165	nucleotide biosynthetic process
GO:0010977	negative regulation of neuron projection development
GO:0043101	purine-containing compound salvage
GO:0044281	small molecule metabolic process
GO:0046070	dGTP metabolic process
GO:0046122	purine deoxyribonucleoside metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process