Version 5.4
Homo sapiens Gene: DGUOK
Summary
InnateDB Gene IDBG-56773.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DGUOK
Gene Name deoxyguanosine kinase
Synonyms dGK; MTDPS3
Species Homo sapiens
Ensembl Gene ENSG00000114956
Encoded Proteins
IDBP-56775
deoxyguanosine kinase
IDBP-56781
deoxyguanosine kinase
IDBP-380240
deoxyguanosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:73926826-73958961
Strand Forward strand
Band p13.1
Transcripts
ENST00000264093 ENSP00000264093
ENST00000348222 ENSP00000306964
ENST00000418996 ENSP00000408209
ENST00000462551
ENST00000489796
ENST00000462685
ENST00000493055
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004138 deoxyguanosine kinase activity
GO:0005524 ATP binding
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019206 nucleoside kinase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006144 purine nucleobase metabolic process
GO:0006468 protein phosphorylation
GO:0008617 guanosine metabolic process
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0010977 negative regulation of neuron projection development
GO:0043101 purine-containing compound salvage
GO:0044281 small molecule metabolic process
GO:0046070 dGTP metabolic process
GO:0046122 purine deoxyribonucleoside metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014554
View Gene Order
ENSBTAG00000012037
Not yet available
Pathways
NETPATH
REACTOME
REACT_1923
Purine salvage pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.469022
RefSeq NM_080916 NM_080918
HUGO
OMIM
CCDS CCDS1931 CCDS1932
HPRD 03273
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca