InnateDB Protein
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IDBP-56781.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DGUOK
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Protein Name
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deoxyguanosine kinase
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Synonyms
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dGK; MTDPS3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000306964
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InnateDB Gene
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IDBG-56773 (DGUOK)
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Protein Structure
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Function |
Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents. {ECO:0000269PubMed:8706825}.
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Subcellular Localization |
Mitochondrion.
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Disease Associations |
Mitochondrial DNA depletion syndrome 3 (MTDPS3) [MIM:251880]: A disorder due to mitochondrial dysfunction characterized by onset in infancy of progressive liver failure, hypoglycemia, increased lactate in body fluids, and neurologic abnormalities including hypotonia, encephalopathy, peripheral neuropathy. Affected tissues show both decreased activity of the mtDNA-encoded respiratory chain complexes and mtDNA depletion. {ECO:0000269PubMed:12205643, ECO:0000269PubMed:15639197}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues. {ECO:0000269PubMed:8706825}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006139
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nucleobase-containing compound metabolic process
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GO:0006144
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purine nucleobase metabolic process
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GO:0008617
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guanosine metabolic process
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GO:0009157
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deoxyribonucleoside monophosphate biosynthetic process
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GO:0009165
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nucleotide biosynthetic process
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GO:0043101
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purine-containing compound salvage
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GO:0044281
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small molecule metabolic process
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GO:0046122
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purine deoxyribonucleoside metabolic process
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GO:0055086
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nucleobase-containing small molecule metabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR002624
Deoxynucleoside kinase
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF01712
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PRINTS |
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PIRSF |
PIRSF000705
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q16854
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PhosphoSite |
PhosphoSite-Q16854
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TrEMBL |
Q9BVK7
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UniProt Splice Variant |
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Entrez Gene |
1716
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UniGene |
Hs.469022
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RefSeq |
NP_550440
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HUGO |
HGNC:2858
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OMIM |
601465
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CCDS |
CCDS1932
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HPRD |
03273
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IMGT |
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EMBL |
AC073046
BC001121
BC015757
CH471053
HQ206026
HQ206027
HQ206028
HQ206029
HQ206030
HQ206031
HQ206032
HQ206033
HQ206034
HQ206035
HQ206036
HQ206037
HQ206038
HQ206039
HQ206040
HQ206041
HQ206042
HQ206043
HQ206044
HQ206045
HQ206046
HQ206047
HQ206048
HQ206049
HQ206050
HQ206051
HQ206052
HQ206053
HQ206054
HQ206055
HQ206056
HQ206057
HQ206058
HQ206059
HQ206060
HQ206061
HQ206062
HQ206063
HQ206064
HQ206065
U41668
U81499
X97386
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GenPept |
AAB39858
AAC50624
AAH01121
AAH15757
AAX88910
ADP91895
ADP91897
ADP91899
ADP91901
ADP91903
ADP91905
ADP91907
ADP91909
ADP91911
ADP91913
ADP91915
ADP91917
ADP91919
ADP91921
ADP91923
ADP91925
ADP91927
ADP91929
ADP91931
ADP91933
ADP91935
ADP91937
ADP91939
ADP91941
ADP91943
ADP91945
ADP91947
ADP91949
ADP91951
ADP91953
ADP91955
ADP91957
ADP91959
ADP91961
ADP91963
ADP91965
ADP91967
ADP91969
ADP91971
ADP91973
CAA66054
EAW99709
EAW99710
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