InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLA2

Summary

InnateDB Protein

IDBP-56796.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLA2

Protein Name

polymerase (DNA directed), alpha 2 (70kD subunit)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000265465

InnateDB Gene

IDBG-56794 (POLA2)

Protein Structure

UniProt Annotation

Function

May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery. {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	50 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0000722	telomere maintenance via recombination
GO:0000723	telomere maintenance
GO:0006260	DNA replication
GO:0006270	DNA replication initiation
GO:0006271	DNA strand elongation involved in DNA replication
GO:0032201	telomere maintenance via semi-conservative replication