Version 5.4
Homo sapiens Gene: POLA2
Summary
InnateDB Gene IDBG-56794.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLA2
Gene Name polymerase (DNA directed), alpha 2, accessory subunit
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000014138
Encoded Proteins
IDBP-56796
polymerase (DNA directed), alpha 2 (70kD subunit)
IDBP-602494
polymerase (DNA directed), alpha 2 (70kD subunit)
IDBP-597900
polymerase (DNA directed), alpha 2 (70kD subunit)
IDBP-603116
polymerase (DNA directed), alpha 2 (70kD subunit)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:65261762-65305589
Strand Forward strand
Band q13.1
Transcripts
ENST00000265465 ENSP00000265465
ENST00000527850 ENSP00000432536
ENST00000532469
ENST00000532391 ENSP00000433952
ENST00000527618
ENST00000525924 ENSP00000434173
ENST00000533192
ENST00000534785
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0032201 telomere maintenance via semi-conservative replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024833
View Gene Order
ENSBTAG00000011455
Not yet available
Pathways
NETPATH
REACTOME
REACT_7987
Polymerase switching on the C-strand of the telomere pathway
REACT_7993
Telomere C-strand synthesis initiation pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_2244
DNA replication initiation pathway
REACT_70
Removal of the Flap Intermediate pathway
REACT_1385
Processive synthesis on the lagging strand pathway
REACT_1792
Polymerase switching pathway
REACT_1838
Leading Strand Synthesis pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_329
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_7970
Telomere Maintenance pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_8030
Extension of Telomeres pathway
REACT_312
Lagging Strand Synthesis pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa03030
DNA replication pathway
hsa00230
Purine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PIQ6
UniProt Splice Variant
Entrez Gene 23649
UniGene Hs.201897 Hs.659967
RefSeq NM_002689
HUGO HGNC:30073
OMIM
CCDS CCDS8098
HPRD 10160
IMGT
EMBL AP000944
GenPept
RNA Seq Atlas 23649

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca