Version 5.4
Homo sapiens Protein: LRR1
Summary
InnateDB Protein IDBP-5686.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRR1
Protein Name leucine rich repeat protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000315628
InnateDB Gene IDBG-5682 (LRR1)
Protein Structure
UniProt Annotation
Function May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269PubMed:15601820}.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitous. Maximal expression was seen in the heart and skeletal muscle and minimal expression seen in the kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96L50
PhosphoSite PhosphoSite-Q96L50
TrEMBL
UniProt Splice Variant
Entrez Gene 122769
UniGene Hs.451090
RefSeq NP_982292
HUGO HGNC:19742
OMIM 609193
CCDS CCDS9687
HPRD 15164
IMGT
EMBL AK293156 AY052405 BC030142 BC093697 BC112241 BC139921 BX248298 CH471078
GenPept AAH30142 AAH93697 AAI12242 AAI39922 AAL11430 BAG56701 CAD62625 EAW65761

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca