Version 5.4
Homo sapiens Protein: UBA5
Summary
InnateDB Protein IDBP-57122.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBA5
Protein Name ubiquitin-like modifier activating enzyme 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000264991
InnateDB Gene IDBG-57120 (UBA5)
Protein Structure
UniProt Annotation
Function E1-like enzyme which activates UFM1 and SUMO2. {ECO:0000269PubMed:15071506, ECO:0000269PubMed:18442052, ECO:0000269PubMed:20368332}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18442052}. Nucleus {ECO:0000269PubMed:18442052}. Note=Localizes mainly in cytoplasm, while it mainly localizes to the nucleus in presence of SUMO2.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:16328888}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
Experimentally validated
Total 55 [view]
Protein-Protein 54 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0048037 cofactor binding
GO:0071566 UFM1 activating enzyme activity
Biological Process
GO:0034976 response to endoplasmic reticulum stress
GO:0055114 oxidation-reduction process
GO:0071569 protein ufmylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR009036 Molybdenum cofactor biosynthesis, MoeB
PFAM PF00899
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9GZZ9
PhosphoSite PhosphoSite-Q9GZZ9
TrEMBL C9J5W5
UniProt Splice Variant
Entrez Gene 79876
UniGene Hs.707919
RefSeq NP_938143
HUGO HGNC:23230
OMIM 610552
CCDS CCDS3077
HPRD 15598
IMGT
EMBL AB154406 AC020632 AK026904 AK027563 AL136757 AY253672 BC009737 CH471052
GenPept AAH09737 AAP79600 BAB15587 BAB55199 BAD15375 CAB66691 EAW79189 EAW79191 EAW79192

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca