InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBA5

Summary

InnateDB Gene

IDBG-57120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBA5

Gene Name

ubiquitin-like modifier activating enzyme 5

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000081307

Encoded Proteins

IDBP-57122

ubiquitin-like modifier activating enzyme 5

IDBP-57124

ubiquitin-like modifier activating enzyme 5

IDBP-478786

ubiquitin-like modifier activating enzyme 5

IDBP-475175

ubiquitin-like modifier activating enzyme 5

IDBP-482654

ubiquitin-like modifier activating enzyme 5

IDBP-479197

ubiquitin-like modifier activating enzyme 5

IDBP-476266

ubiquitin-like modifier activating enzyme 5

IDBP-482727

ubiquitin-like modifier activating enzyme 5

IDBP-474018

ubiquitin-like modifier activating enzyme 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A pseudogene located on chromosome 1 has also been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:132654446-132678097

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000264991	ENSP00000264991
ENST00000356232	ENSP00000348565
ENST00000480955
ENST00000493720	ENSP00000417879
ENST00000468022	ENSP00000418569
ENST00000464101
ENST00000473651	ENSP00000424984
ENST00000494238	ENSP00000418807
ENST00000505777	ENSP00000427233
ENST00000464068	ENSP00000420055
ENST00000489361	ENSP00000417905
ENST00000468227
ENST00000469158
ENST00000494112

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.

Experimentally validated
Total	55 [view]
Protein-Protein	54 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872	metal ion binding
GO:0048037	cofactor binding
GO:0071566	UFM1 activating enzyme activity

Biological Process

GO:0008152	metabolic process
GO:0034976	response to endoplasmic reticulum stress
GO:0055114	oxidation-reduction process
GO:0071569	protein ufmylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032557

View Gene Order

ENSBTAG00000004495

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

C9J0F6

UniProt Splice Variant

Entrez Gene

79876

UniGene

Hs.170737 Hs.707919

RefSeq

NM_024818 NM_198329 XM_005247787

HUGO

HGNC:23230

OMIM

610552

CCDS

CCDS3076 CCDS3077

HPRD

15598

IMGT

EMBL

AC020632

GenPept

RNA Seq Atlas

79876