InnateDB Protein
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IDBP-57270.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HVCN1
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Protein Name
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hydrogen voltage-gated channel 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000242607
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InnateDB Gene
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IDBG-57264 (HVCN1)
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Protein Structure
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Function |
Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. {ECO:0000269PubMed:16554753, ECO:0000269PubMed:20037153, ECO:0000269PubMed:22020278}.
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Subcellular Localization |
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types.
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Disease Associations |
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Tissue Specificity |
Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen. {ECO:0000269PubMed:16554753}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005821
Ion transport domain
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PFAM |
PF00520
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96D96
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PhosphoSite |
PhosphoSite-Q96D96
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TrEMBL |
F8W0B3
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UniProt Splice Variant |
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Entrez Gene |
84329
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UniGene |
Hs.334637
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RefSeq |
NP_115745
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HUGO |
HGNC:28240
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OMIM |
611227
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CCDS |
CCDS31900
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HPRD |
17507
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IMGT |
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EMBL |
AC144522
AK293543
AY359054
BC007277
BC009731
BC032672
CH471054
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GenPept |
AAH07277
AAH09731
AAH32672
AAQ89413
BAG57024
EAW97935
EAW97936
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