Version 5.4
Homo sapiens Gene: HVCN1
Summary
InnateDB Gene IDBG-57264.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HVCN1
Gene Name hydrogen voltage-gated channel 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000122986
Encoded Proteins
IDBP-57266
hydrogen voltage-gated channel 1
IDBP-57270
hydrogen voltage-gated channel 1
IDBP-383317
hydrogen voltage-gated channel 1
IDBP-599410
hydrogen voltage-gated channel 1
IDBP-598646
hydrogen voltage-gated channel 1
IDBP-591061
hydrogen voltage-gated channel 1
IDBP-597692
hydrogen voltage-gated channel 1
IDBP-807102
hydrogen voltage-gated channel 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:110627841-110704950
Strand Reverse strand
Band q24.11
Transcripts
ENST00000356742 ENSP00000349181
ENST00000242607 ENSP00000242607
ENST00000439744 ENSP00000412052
ENST00000548312 ENSP00000449601
ENST00000549442 ENSP00000450106
ENST00000547887 ENSP00000448379
ENST00000546713 ENSP00000447227
ENST00000546425
ENST00000620084 ENSP00000479812
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0022843 voltage-gated cation channel activity
GO:0030171 voltage-gated proton channel activity
Biological Process
GO:0006811 ion transport
GO:0007338 single fertilization
GO:0009268 response to pH
GO:0010043 response to zinc ion
GO:0015992 proton transport
GO:0032504 multicellular organism reproduction
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035036 sperm-egg recognition
GO:0055085 transmembrane transport
GO:0071294 cellular response to zinc ion
GO:0071467 cellular response to pH
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000064267
View Gene Order
ENSBTAG00000009216
Not yet available
Pathways
NETPATH
REACTOME
REACT_163914
Fertilization pathway
REACT_163875
Sperm Motility And Taxes pathway
REACT_163848
Reproduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.334637
RefSeq NM_001040107 NM_001256413 NM_032369 XM_005253948 XM_006719640
HUGO
OMIM
CCDS CCDS31900 CCDS58278
HPRD 17507
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca