InnateDB Protein
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IDBP-57307.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPP1CC
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Protein Name
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protein phosphatase 1, catalytic subunit, gamma isozyme
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Synonyms
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PP-1G; PP1C; PPP1G;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000341779
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InnateDB Gene
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IDBG-57303 (PPP1CC)
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Protein Structure
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Function |
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. {ECO:0000269PubMed:17936702, ECO:0000269PubMed:20516061, ECO:0000269PubMed:21712997}.
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Subcellular Localization |
Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Note=Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion. Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 239 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated |
Total |
239
[view]
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Protein-Protein |
237
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
31 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004843
Calcineurin-like phosphoesterase domain, apaH type
IPR006186
Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052
Metallo-dependent phosphatase-like
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PFAM |
PF00149
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PRINTS |
PR00114
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PIRSF |
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SMART |
SM00156
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TIGRFAMs |
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Modification |
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SwissProt |
P36873
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PhosphoSite |
PhosphoSite-P36873
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TrEMBL |
Q9UPN1
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UniProt Splice Variant |
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Entrez Gene |
5501
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UniGene |
Hs.79081
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RefSeq |
NP_001231903
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HUGO |
HGNC:9283
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OMIM |
176914
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CCDS |
CCDS58279
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HPRD |
08911
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IMGT |
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EMBL |
AB030255
AB505431
AB505433
BC014073
L07395
X74008
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GenPept |
AAA19823
AAH14073
BAA82664
BAH69083
BAH69084
CAA52169
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