Version 5.4
Homo sapiens Protein: UBE2Z
Summary
InnateDB Protein IDBP-57323.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2Z
Protein Name ubiquitin-conjugating enzyme E2Z
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000354201
InnateDB Gene IDBG-57321 (UBE2Z)
Protein Structure
UniProt Annotation
Function Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. {ECO:0000255PROSITE-ProRule:PRU00388, ECO:0000269PubMed:17464193, ECO:0000269PubMed:17597759}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17160626}. Nucleus {ECO:0000269PubMed:17160626}.
Disease Associations
Tissue Specificity Widely expressed. Highly in placenta, pancreas, spleen and testis. {ECO:0000269PubMed:17160626, ECO:0000269PubMed:17597759}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0006915 apoptotic process
GO:0008152 metabolic process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
PFAM PF00179
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H832
PhosphoSite PhosphoSite-Q9H832
TrEMBL I3L4C5
UniProt Splice Variant
Entrez Gene 65264
UniGene Hs.622044
RefSeq NP_075567
HUGO HGNC:25847
OMIM 611362
CCDS CCDS11540
HPRD 08589
IMGT
EMBL AB025426 AC091133 AK023917 AK024030 AL713782 BC015169 BC015890 CH471109 CR457322 EF623992
GenPept AAH15169 AAH15890 ABR25252 BAB14724 BAB14789 BAB87810 CAD28542 CAG33603 EAW94703

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca