Version 5.4
Homo sapiens Gene: UBE2Z
Summary
InnateDB Gene IDBG-57321.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2Z
Gene Name ubiquitin-conjugating enzyme E2Z
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159202
Encoded Proteins
IDBP-57323
ubiquitin-conjugating enzyme E2Z
IDBP-483098
ubiquitin-conjugating enzyme E2Z
IDBP-473518
ubiquitin-conjugating enzyme E2Z
IDBP-763351
IDBP-764656
IDBP-762909
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48908369-48929056
Strand Forward strand
Band q21.32
Transcripts
ENST00000360943 ENSP00000354201
ENST00000508468 ENSP00000424543
ENST00000506498 ENSP00000425398
ENST00000511373 ENSP00000461147
ENST00000504684 ENSP00000460759
ENST00000513342
ENST00000506271
ENST00000514948 ENSP00000459473
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0006915 apoptotic process
GO:0008152 metabolic process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014349
View Gene Order
ENSBTAG00000018802
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.514297 Hs.593680 Hs.604998 Hs.622044
RefSeq NM_023079
HUGO
OMIM
CCDS CCDS11540
HPRD 08589
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca