InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CUX2

Summary

InnateDB Protein

IDBP-57421.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CUX2

Protein Name

cut-like homeobox 2

Synonyms

CDP2; CUTL2;

Species

Homo sapiens

Ensembl Protein

ENSP00000261726

InnateDB Gene

IDBG-57419 (CUX2)

Protein Structure

UniProt Annotation

Function

May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000255PROSITE-ProRule:PRU00374}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007614	short-term memory
GO:0010628	positive regulation of gene expression
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050775	positive regulation of dendrite morphogenesis
GO:0050890	cognition
GO:0051965	positive regulation of synapse assembly
GO:0061003	positive regulation of dendritic spine morphogenesis
GO:0071310	cellular response to organic substance
GO:2000463	positive regulation of excitatory postsynaptic membrane potential