Version 5.4
Homo sapiens Gene: CUX2
Summary
InnateDB Gene IDBG-57419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CUX2
Gene Name cut-like homeobox 2
Synonyms CDP2; CUTL2
Species Homo sapiens
Ensembl Gene ENSG00000111249
Encoded Proteins
IDBP-57421
cut-like homeobox 2
IDBP-234920
cut-like homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:111034024-111350554
Strand Forward strand
Band q24.11
Transcripts
ENST00000261726 ENSP00000261726
ENST00000397643 ENSP00000380765
ENST00000551604
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007614 short-term memory
GO:0010628 positive regulation of gene expression
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050775 positive regulation of dendrite morphogenesis
GO:0050890 cognition
GO:0051965 positive regulation of synapse assembly
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0071310 cellular response to organic substance
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042589
View Gene Order
ENSBTAG00000008571
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.124953
RefSeq NM_015267 XM_006719299
HUGO
OMIM
CCDS CCDS41837
HPRD 10851
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca