Version 5.4
Homo sapiens Protein: B4GALNT2
Summary
InnateDB Protein IDBP-57463.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol B4GALNT2
Protein Name beta-1,4-N-acetyl-galactosaminyl transferase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000300404
InnateDB Gene IDBG-57461 (B4GALNT2)
Protein Structure
UniProt Annotation
Function Involved in the synthesis of the Sd(a) antigen (Sia- alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain. {ECO:0000269PubMed:12678917, ECO:0000269PubMed:14688233}.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed. Highly expressed in colon and to a lesser extent in kidney, stomach, ileum and rectum. {ECO:0000269PubMed:12678917}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008376 acetylgalactosaminyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
Biological Process
GO:0006047 UDP-N-acetylglucosamine metabolic process
GO:0006486 protein glycosylation
GO:0019276 UDP-N-acetylgalactosamine metabolic process
GO:0022408 negative regulation of cell-cell adhesion
GO:0030259 lipid glycosylation
Cellular Component
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
Protein Structure and Domains
PDB ID
InterPro IPR001173 Glycosyltransferase 2-like
IPR011143 Ganglioside GM2 synthase
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF00535
PRINTS
PIRSF PIRSF000474
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NHY0
PhosphoSite PhosphoSite-Q8NHY0
TrEMBL Q8IVI2
UniProt Splice Variant
Entrez Gene 124872
UniGene Hs.374679
RefSeq NP_703147
HUGO HGNC:24136
OMIM 111730
CCDS CCDS11544
HPRD 13558
IMGT
EMBL AC069454 AF510036 AJ517770 AJ517771 AK302876 BC113675 BC113677 CH471109 S83275
GenPept AAI13676 AAI13678 AAM34756 AAN86706 BAG64056 CAD57148 CAD57149 EAW94691

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca