InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFX1

Summary

InnateDB Protein

IDBP-57495.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFX1

Protein Name

nuclear transcription factor, X-box binding 1

Synonyms

NFX2; TEG-42; Tex42;

Species

Homo sapiens

Ensembl Protein

ENSP00000368856

InnateDB Gene

IDBG-57493 (NFX1)

Protein Structure

UniProt Annotation

Function

Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination. {ECO:0000269PubMed:10500182, ECO:0000269PubMed:15371341, ECO:0000269PubMed:17267499}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006954	inflammatory response
GO:0016032	viral process
GO:0045347	negative regulation of MHC class II biosynthetic process

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000967 Zinc finger, NF-X1-type
IPR001374 Single-stranded nucleic acid binding R3H
IPR001841 Zinc finger, RING-type
IPR019787 Zinc finger, PHD-finger

PFAM

PF01422
PF01424
PF13639
PF14634
PF00628

PRINTS

PIRSF

SMART

SM00438
SM00393
SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q12986