Version 5.4
Homo sapiens Gene: NFX1
Summary
InnateDB Gene IDBG-57493.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFX1
Gene Name nuclear transcription factor, X-box binding 1
Synonyms NFX2; TEG-42; Tex42
Species Homo sapiens
Ensembl Gene ENSG00000086102
Encoded Proteins
IDBP-57495
nuclear transcription factor, X-box binding 1
IDBP-57499
nuclear transcription factor, X-box binding 1
IDBP-57501
nuclear transcription factor, X-box binding 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:33290511-33371157
Strand Forward strand
Band p13.3
Transcripts
ENST00000379540 ENSP00000368856
ENST00000379521 ENSP00000368836
ENST00000318524 ENSP00000317695
ENST00000466359
ENST00000466971
ENST00000463421
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006954 inflammatory response
GO:0016032 viral process
GO:0045347 negative regulation of MHC class II biosynthetic process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028423
View Gene Order
ENSBTAG00000012385
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
Tryptophan degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.413074
RefSeq NM_002504 NM_147133 NM_147134 XM_005251473 XM_005251474 XM_005251475 XM_006716776
HUGO
OMIM
CCDS CCDS6538 CCDS6539 CCDS6540
HPRD 11936
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca