InnateDB Protein
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IDBP-57597.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TLX2
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Protein Name
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T-cell leukemia homeobox 2
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Synonyms
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HOX11L1; NCX;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000233638
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InnateDB Gene
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IDBG-57593 (TLX2)
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Protein Structure
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Function |
Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
|
Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
IPR020479
Homeodomain, metazoa
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PFAM |
PF00046
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PRINTS |
PR00024
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
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Modification |
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SwissProt |
O43763
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PhosphoSite |
PhosphoSite-O43763
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
3196
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UniGene |
Hs.168586
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RefSeq |
NP_057254
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HUGO |
HGNC:5057
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OMIM |
604240
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CCDS |
CCDS1947
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HPRD |
07254
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IMGT |
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EMBL |
AB008501
AC005041
AJ002607
AJ002608
AJ002609
BC006356
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GenPept |
AAH06356
BAA83463
CAA05636
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