InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OVOL1

Summary

InnateDB Protein

IDBP-57739.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OVOL1

Protein Name

ovo-like 1(Drosophila)

Synonyms

HOVO1;

Species

Homo sapiens

Ensembl Protein

ENSP00000337862

InnateDB Gene

IDBG-57737 (OVOL1)

Protein Structure

UniProt Annotation

Function

Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in fetal kidney, and also in adult pancreas and placenta. Not expressed in intestine, peripheral blood lymphocytes and ovary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001822	kidney development
GO:0006366	transcription from RNA polymerase II promoter
GO:0007010	cytoskeleton organization
GO:0007283	spermatogenesis
GO:0007498	mesoderm development
GO:0008544	epidermis development
GO:0009913	epidermal cell differentiation
GO:0043588	skin development
GO:0051729	germline cell cycle switching, mitotic to meiotic cell cycle
GO:1901994	negative regulation of meiotic cell cycle phase transition