InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HTRA2

Summary

InnateDB Protein

IDBP-57755.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTRA2

Protein Name

HtrA serine peptidase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000258080

InnateDB Gene

IDBG-57753 (HTRA2)

Protein Structure

UniProt Annotation

Function

Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. {ECO:0000269PubMed:15200957, ECO:0000269PubMed:19502560}.

Subcellular Localization

Mitochondrion intermembrane space. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.

Disease Associations

Parkinson disease 13 (PARK13) [MIM:610297]: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. {ECO:0000269PubMed:15961413}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	64 [view]
Protein-Protein	63 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0051082	unfolded protein binding

Biological Process

GO:0006508	proteolysis
GO:0006672	ceramide metabolic process
GO:0007005	mitochondrion organization
GO:0007628	adult walking behavior
GO:0008344	adult locomotory behavior
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009635	response to herbicide
GO:0010942	positive regulation of cell death
GO:0016540	protein autoprocessing
GO:0019742	pentacyclic triterpenoid metabolic process
GO:0030900	forebrain development
GO:0034605	cellular response to heat
GO:0040014	regulation of multicellular organism growth
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045786	negative regulation of cell cycle
GO:0048666	neuron development
GO:0060548	negative regulation of cell death
GO:0071363	cellular response to growth factor stimulus
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097194	execution phase of apoptosis
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0009898	cytoplasmic side of plasma membrane
GO:0016020	membrane
GO:0031966	mitochondrial membrane
GO:0035631	CD40 receptor complex