Version 5.4
Homo sapiens Protein: MUS81
Summary
InnateDB Protein IDBP-57862.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MUS81
Protein Name MUS81 endonuclease homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000307853
InnateDB Gene IDBG-57860 (MUS81)
Protein Structure
UniProt Annotation
Function Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269PubMed:11741546, ECO:0000269PubMed:12374758, ECO:0000269PubMed:12686547, ECO:0000269PubMed:12721304, ECO:0000269PubMed:14617801, ECO:0000269PubMed:15805243, ECO:0000269PubMed:17289582, ECO:0000269PubMed:19595721, ECO:0000269PubMed:19596235}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:11741546, ECO:0000269PubMed:14617801, ECO:0000269PubMed:14638871, ECO:0000269PubMed:15805243}. Note=Recruited to foci of DNA damage in S-phase cells.
Disease Associations
Tissue Specificity Widely expressed.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0048257 3'-flap endonuclease activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0072429 response to intra-S DNA damage checkpoint signaling
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0045171 intercellular bridge
Protein Structure and Domains
PDB ID
InterPro IPR006166 ERCC4 domain
IPR010996 DNA polymerase beta-like, N-terminal domain
IPR011335 Restriction endonuclease type II-like
PFAM PF02732
PRINTS
PIRSF
SMART SM00891
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96NY9
PhosphoSite PhosphoSite-Q96NY9
TrEMBL H0YE94
UniProt Splice Variant
Entrez Gene 80198
UniGene Hs.288798
RefSeq NP_079404
HUGO HGNC:29814
OMIM 606591
CCDS CCDS8115
HPRD 09419
IMGT
EMBL AF425646 AK024665 AP001201 AP001266 BC009999
GenPept AAH09999 AAL28065 BAB14953

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca