InnateDB Protein
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IDBP-57873.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TAC4
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Protein Name
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tachykinin 4 (hemokinin)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000325286
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InnateDB Gene
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IDBG-57869 (TAC4)
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Protein Structure
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Function |
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility. {ECO:0000269PubMed:12716968, ECO:0000269PubMed:17101218, ECO:0000269PubMed:17437961, ECO:0000269PubMed:17655832}.
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Subcellular Localization |
Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta. {ECO:0000269PubMed:12716968, ECO:0000269PubMed:12788812}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86UU9
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
729220
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UniGene |
Hs.652130
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RefSeq |
NP_001070972
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HUGO |
HGNC:16641
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OMIM |
607833
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CCDS |
CCDS42360
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HPRD |
09701
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IMGT |
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EMBL |
AF515828
AF515829
AF515830
AF515831
AF521560
AY471574
BC100840
BC100842
BC100843
CH471109
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GenPept |
AAI00841
AAI00843
AAI00844
AAN77128
AAP30874
AAP30875
AAP30876
AAP30877
AAS46596
EAW94657
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