Version 5.4
Homo sapiens Protein: TRAFD1
Summary
InnateDB Protein IDBP-57923.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAFD1
Protein Name TRAF-type zinc finger domain containing 1
Synonyms FLN29;
Species Homo sapiens
Ensembl Protein ENSP00000257604
InnateDB Gene IDBG-57921 (TRAFD1)
Protein Structure
UniProt Annotation
Function Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0034097 response to cytokine
GO:0045087 innate immune response (InnateDB)
GO:0045824 negative regulation of innate immune response
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR008974 TRAF-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14545
PhosphoSite PhosphoSite-O14545
TrEMBL S4R2Z9
UniProt Splice Variant
Entrez Gene 10906
UniGene Hs.618023
RefSeq NP_001137378
HUGO HGNC:24808
OMIM 613197
CCDS CCDS9160
HPRD 10994
IMGT
EMBL AB007447 AC073575 AK291331 BC003553 CH471054
GenPept AAH03553 BAA22541 BAF84020 EAW97995 EAW97996 EAW97997

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca