InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AQP3

Summary

InnateDB Protein

IDBP-57962.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AQP3

Protein Name

aquaporin 3 (Gill blood group)

Synonyms

AQP-3; GIL;

Species

Homo sapiens

Ensembl Protein

ENSP00000297991

InnateDB Gene

IDBG-57960 (AQP3)

Protein Structure

UniProt Annotation

Function

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity). {ECO:0000250}.

Subcellular Localization

Basolateral cell membrane; Multi-pass membrane protein. Note=In collecting ducts of kidney.

Disease Associations

Tissue Specificity

Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0015250	water channel activity
GO:0015254	glycerol channel activity

Biological Process

GO:0002684	positive regulation of immune system process
GO:0006810	transport
GO:0006833	water transport
GO:0007588	excretion
GO:0015793	glycerol transport
GO:0015840	urea transport
GO:0032526	response to retinoic acid
GO:0033280	response to vitamin D
GO:0042476	odontogenesis
GO:0045087	innate immune response (InnateDB)
GO:0045616	regulation of keratinocyte differentiation
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport
GO:0070295	renal water absorption

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane