InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AQP3

Summary

InnateDB Gene

IDBG-57960.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AQP3

Gene Name

aquaporin 3 (Gill blood group)

Synonyms

AQP-3; GIL

Species

Homo sapiens

Ensembl Gene

ENSG00000165272

Encoded Proteins

IDBP-57962

aquaporin 3 (Gill blood group)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21865318

AQP3 is an aquaporin that functions in macrophage immunity by a cellular mechanism involving facilitated water and glycerol transport, and consequent phagocytic and migration activity. AQP3, therefore, is a novel therapeutic target in modulating the innate immune response in various infectious and inflammatory conditions.

InnateDB Annotation from Orthologs

Summary

PMID 21865318

[Mus musculus] Aqp3 is an aquaporin that functions in macrophage immunity by a cellular mechanism involving facilitated water and glycerol transport, and consequent phagocytic and migration activity. Aqp3, therefore, is a novel therapeutic target in modulating the innate immune response in various infectious and inflammatory conditions.

Entrez Gene

Summary

This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:33441154-33447611

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000297991	ENSP00000297991
ENST00000493581
ENST00000494313
ENST00000463983
ENST00000473153

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0015250	water channel activity
GO:0015254	glycerol channel activity

Biological Process

GO:0002684	positive regulation of immune system process
GO:0006810	transport
GO:0006833	water transport
GO:0007588	excretion
GO:0015793	glycerol transport
GO:0015840	urea transport
GO:0032526	response to retinoic acid
GO:0033280	response to vitamin D
GO:0042476	odontogenesis
GO:0045087	innate immune response (InnateDB)
GO:0045616	regulation of keratinocyte differentiation
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport
GO:0070295	renal water absorption

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028435

View Gene Order

ENSBTAG00000008493

Not yet available

Pathways

NETPATH

REACTOME

REACT_23826

Passive transport by Aquaporins pathway

REACT_24023

Vasopressin regulates renal water homeostasis via Aquaporins pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_23887

Aquaporin-mediated transport pathway

KEGG

hsa04962

Vasopressin-regulated water reabsorption pathway

INOH

PID NCI

ecadherin_stabilization_pathway

Stabilization and expansion of the E-cadherin adherens junction

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.234642

RefSeq

NM_004925

HUGO

OMIM

CCDS

CCDS6542

HPRD

08970

IMGT

EMBL

GenPept

RNA Seq Atlas