InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BNIP1

Summary

InnateDB Protein

IDBP-57977.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BNIP1

Protein Name

BCL2/adenovirus E1B 19kDa interacting protein 1

Synonyms

NIP1; SEC20; TRG-8;

Species

Homo sapiens

Ensembl Protein

ENSP00000231668

InnateDB Gene

IDBG-57973 (BNIP1)

Protein Structure

UniProt Annotation

Function

SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy. {ECO:0000269PubMed:15272311, ECO:0000269PubMed:21931693}.

Subcellular Localization

Mitochondrion. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Disease Associations

Tissue Specificity

Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine. {ECO:0000269PubMed:10217402}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	8 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005484	SNAP receptor activity
GO:0005515	protein binding

Biological Process

GO:0006914	autophagy
GO:0006915	apoptotic process
GO:0007029	endoplasmic reticulum organization
GO:0016192	vesicle-mediated transport
GO:0016320	endoplasmic reticulum membrane fusion
GO:0043066	negative regulation of apoptotic process
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0031201	SNARE complex
GO:0043231	intracellular membrane-bounded organelle